Leukocyte?endothelial cell interactions

Cell–cell and cell–matrix interactions

Roles of cell protrusions as initial and dynamic mediators of cell–cell and cell–ECM interactions Filopodia have well-established roles in sampling the local environment and making initial cell–ECM contacts at the leading edge of many cell types. Filopodial-like structures, termed “epithelial zippers,” can mediate initial contacts between epithelial cells that culminate in assembly of cell–cell...

Cell–cell and cell–matrix interactions

Intracellular interactions shape cells Intestinal epithelial cells build a brush border of microvilli at their apical surfaces that mediates nutrient absorption and host defense. Scott Crawley (Tyska Laboratory, Vanderbilt University Medical Center) showed that brush border assembly is driven by trans interactions between protocadherin-24 and mucin-like protocadherin at the tips of adjacent mic...

Endothelial Cell- Astrocyte Interactions

Recent advances in cell biology open the way for studying aspects of blood-brain bamer (BBB) formation and function that have puzzled investigators since Ehrlich and Goldmann first described the barrier. Although the endothelial cells in the microvessels of all tissues appear to arise from common mesodermal precursors, considerable organ-to-organ variability exists in their ultrastructure and p...

Studying Fibrin-Cell Interactions

Mast Cell-Nerve Interactions.

Mutual associations between nerves and mast cells have been observed in normal conditions and in pathological ones such as human irritable bowel syndrome, atopic dermatitis, interstitial cystitis, and more. Here we review the recent literature in this field, putting emphasis on the enteric, skin, and urinary systems, and the pathophysiological implications of this interaction in them.